AREDS II Eye Study Addresses Beta-Carotene Problems

By Teri Farley


Age-Related Eye Disease Study II, or AREDS II, is a study that looked at how nutrients affect eyesight. The initial study, completed in 2001, showed that high levels of antioxidants sometimes reduced the risk of developing blindness by 25 percent. There were some problems found after the study though and the subsequent study looked at those issues.


Eye diseases are some of the most debilitating. Almost a million people in the United States are blind and around 90% of these are elderly. There are several different reasons someone might end up with an eye disease. Some people are born blind due to defects during the gestation period. Others are caused by diabetes or eye injury. However, most appear to be associated with aging, such as age-related macular degeneration (AMD) and cataracts.

Most treatments that exist today are only good for a limited range of eye diseases and have limited efficacy. One of the most common currently available treatments is laser surgery; while it has been shown to reduce the risks of blindness, the surgery is very costly and could even result in complications. Although not usually severe, the side effects are quite common; some of these include loss of peripheral vision, reduced night vision, worsening visual acuity, and even hemorrhaging.

The first Age-Related Eye Disease Study was released in 2001. The purpose of this study was to learn more about the risk factors surrounding age-related macular degeneration and cataracts and to research the history of the victims. They also wanted to determine whether high doses of antioxidants, including vitamins C and E, beta-carotene, and zinc would have any effect on AMD and cataracts.

In the first study, the researchers found that a high level of antioxidants could reduce the possibility of blindness in high risk individuals by about 25 percent. High risk individuals were those who either already had intermediate AMD or AMD in only one of their eyes. However, one ingredient of the original formula was beta-carotene, which has been linked to an increase in risk of lung cancer for smokers. Additionally, there was no effect on cataracts.

The second study, completed in May 2013, had several interesting findings. One of their goals was to attempt to find a substitute for beta-carotene in the original formula. They found that the antioxidants lutein and zeaxanthin could be substituted for beta-carotene without reducing the effectiveness of this formula. People at high risk for developing advanced AMD should consider taking the antioxidant combination to reduce their chance of blindness.

A lot of the elderly are already on various prescriptions. In addition to this they may use over-the-counter drugs or supplements. The high-dose supplements in this combination could interfere or cause some of these medications to lose their effectiveness.

There are definitely beneficial effects of laser surgery although this is expensive and can have complications. A safer alternative may be the formulation developed in the AREDS II study. The study confirmed that high levels of zinc and antioxidants reduced the risk of AMD. The study further showed that lutein and zeaxanthin could be substituted for beta-carotene with no reduction in benefits. Of course, before using any medication you should always consult your doctor.



About the Author:



Share on Google Plus
    Blogger Comment
    Facebook Comment

See Also